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PHA 665752, Tocris Bioscience™ Available on GSA/VA Contract for Federal Government customers only.

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Quantity:
10mg
50mg
This item is not returnable. View return policy
477575-56-7
C32H34Cl2N4O4S
641.608
OYONTEXKYJZFHA-SSHUPFPWSA-N
unii-0vxu5t5r3j,2r-1-5-z-5-2,6-dichlorophenyl methyl sulfonyl-1,2-dihydro-2-oxo-3h-indol-3-ylidene methyl-2,4-dimethyl-1h-pyrrol-3-yl carbonyl-2-1-pyrrolidinylmethyl pyrrolidine,0vxu5t5r3j,r,z-5-2,6-dichlorobenzylsulfonyl-3-3,5-dimethyl-4-2-pyrrolidin-1-ylmethyl pyrrolidine-1-carbonyl-1h-pyrrol-2-yl methylene indolin-2-one,pha-665752 hydrate,3z-5-2,6-dichlorophenyl methanesulfonyl-3-3,5-dimethyl-4-2r-2-pyrrolidin-1-ylmethyl pyrrolidine-1-carbonyl-1h-pyrrol-2-yl methylidene-1h-indol-2-one,3z-5-2,6-dichlorophenyl methylsulfonyl-3-3,5-dimethyl-4-2r-2-pyrrolidin-1-ylmethyl pyrrolidine-1-carbonyl-1h-pyrrol-2-yl methylidene-1h-indol-2-one,r,z-5-2,6-dichlorobenzyl sulfonyl-3-3,5-dimethyl-4-2-pyrrolidin-1-ylmethyl pyrrolidine-1-carbonyl-1h-pyrrol-2-yl methylene indolin-2-one,3z-5-2,6-dichlorophenyl methyl sulfonyl-3-3,5-dimethyl-4-2r-2-1-pyrrolidinylmethyl-1-pyrrolidinyl carbonyl-1h-pyrrol-2-yl methylene-1,3-dihydro-2h-indol-2-one hydrate,d00tbd
10461815
(3Z)-5-[(2,6-dichlorophenyl)methylsulfonyl]-3-[[3,5-dimethyl-4-[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl]-1H-pyrrol-2-yl]methylidene]-1H-indol-2-one
CC1=C(NC(=C1C(=O)N2CCCC2CN3CCCC3)C)C=C4C5=C(C=CC(=C5)S(=O)(=O)CC6=C(C=CC=C6Cl)Cl)NC4=O
This item is not returnable. View return policy
477575-56-7
C32H34Cl2N4O4S
641.608
OYONTEXKYJZFHA-SSHUPFPWSA-N
unii-0vxu5t5r3j,2r-1-5-z-5-2,6-dichlorophenyl methyl sulfonyl-1,2-dihydro-2-oxo-3h-indol-3-ylidene methyl-2,4-dimethyl-1h-pyrrol-3-yl carbonyl-2-1-pyrrolidinylmethyl pyrrolidine,0vxu5t5r3j,r,z-5-2,6-dichlorobenzylsulfonyl-3-3,5-dimethyl-4-2-pyrrolidin-1-ylmethyl pyrrolidine-1-carbonyl-1h-pyrrol-2-yl methylene indolin-2-one,pha-665752 hydrate,3z-5-2,6-dichlorophenyl methanesulfonyl-3-3,5-dimethyl-4-2r-2-pyrrolidin-1-ylmethyl pyrrolidine-1-carbonyl-1h-pyrrol-2-yl methylidene-1h-indol-2-one,3z-5-2,6-dichlorophenyl methylsulfonyl-3-3,5-dimethyl-4-2r-2-pyrrolidin-1-ylmethyl pyrrolidine-1-carbonyl-1h-pyrrol-2-yl methylidene-1h-indol-2-one,r,z-5-2,6-dichlorobenzyl sulfonyl-3-3,5-dimethyl-4-2-pyrrolidin-1-ylmethyl pyrrolidine-1-carbonyl-1h-pyrrol-2-yl methylene indolin-2-one,3z-5-2,6-dichlorophenyl methyl sulfonyl-3-3,5-dimethyl-4-2r-2-1-pyrrolidinylmethyl-1-pyrrolidinyl carbonyl-1h-pyrrol-2-yl methylene-1,3-dihydro-2h-indol-2-one hydrate,d00tbd
10461815
(3Z)-5-[(2,6-dichlorophenyl)methylsulfonyl]-3-[[3,5-dimethyl-4-[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl]-1H-pyrrol-2-yl]methylidene]-1H-indol-2-one
CC1=C(NC(=C1C(=O)N2CCCC2CN3CCCC3)C)C=C4C5=C(C=CC(=C5)S(=O)(=O)CC6=C(C=CC=C6Cl)Cl)NC4=O

Potent and selective MET inhibitor

Potent, selective and ATP-competitive inhibitor of MET kinase (IC 50 values are 9, 68, 200, 1400, 3000, 3800 and 6000 nM for MET, Ron, Flk-1, c-abl, FGFR1, EGFR and c-src respectively and > 10000 nM for IGF-IR, PDGFR, AURORA2, PKA, PKBα, p38α, MK2 and MK3). Antitumor agent; inhibits tumorigenicity and angiogenesis in mouse lung cancer xenografts.

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Quantity 10mg
Formula Weight 641.61
Percent Purity >98%
Chemical Name or Material PHA 665752

Recommended Storage : Store at +4°C