Invitrogen™ PHAX Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA564440

Catalog No. PIPA564440

Description

Immunogen sequence: ESQEHTKDLD KELDEYMHGG KKMGSKEEEN GQGHLKRKRP VKDRLGNRPE MNYKGRYEIT AEDSQEKVAD EISFRLQEPK KDLI Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 87%.

A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner. Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.

Specifications

• Antigen: PHAX
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PHAX
• Gene Alias: 26 kDa resiniferatoxin-binding protein; 2810055C14Rik; 4933427L19Rik; AU018701; AU018854; cytosolic resiniferatoxin-binding protein; D18Ertd65e; p55; PHAX; Phosphorylated adapter RNA export protein; phosphorylated adaptor for RNA export; phosphorylation regulated; RBP-2; RBP-26; resiniferatoxin-binding protein 2; RNA U small nuclear RNA export adapter protein; RNA U, small nuclear RNA export adapter (phosphorylation regulated); RNA U, small nuclear RNA export adaptor; RNA U, small nuclear RNA export adaptor (phosphorylation regulated); Rnuxa; RTX-42
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51808
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9H814
• Gene Symbols: PHAX
• Immunogen: Recombinant protein corresponding to Human PHAX. Recombinant protein control fragment (Product #RP-104154).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG