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  6. Phc1 Monoclonal Antibody (6-1-3), Active Motif™ 

Phc1 Monoclonal Antibody (6-1-3), Active Motif™
SDP

Catalog No. 501992806
Encompass
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50-199-2806 10 μg
50-199-2805 100 μg
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Catalog No. 50-199-2806 Supplier Active Motif Supplier No. 39724
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Description

Mouse Monoclonal Antibody

Polycomb group (PcG) proteins assemble into multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes throughout development. PHC1 (polyhomeotic homolog 1), also known as EDR1, HPH1 or RAE28, is a 1,004 amino acid nuclear protein that is a component of the PcG multiprotein PRC1 complex. Specifically, the PcG PRC1 complex modifies histones, remodels chromatin and mediates monoubiquination of Histone H2A. Other constituent proteins involved in the PcG PRC1 complex are Mel-18, Bmi-1, M33, MPc2, MPc3, RING1, Ring1b, as well as several others. Existing as a homodimer, PHC1 contains one FCS-type zinc finger and a SAM (sterile alpha motif) domain. PHC1 is encoded by a gene located on human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome.

Specifications

Antigen Phc1
Applications Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 6-1-3
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene PHC1
Gene Accession No. P78364, Q64028
Gene Alias AW557034; BOS_5916; DKFZp686A1782; early development regulator 1 (homolog of polyhomeotic 1); early development regulator1 (homolog of polyhomeotic 1); Early development regulatory protein 1; Edr; Edr1; hPH1; LOC100347568; MCPH11; mPH1; PH1; PHC1; polyhomeotic 1-like; polyhomeotic homolog 1; polyhomeotic homolog 1 (Drosophila); polyhomeotic-like 1; polyhomeotic-like 1 (Drosophila); Polyhomeotic-like protein 1; Rae28; RAE-28
Gene Symbols PHC1
Host Species Mouse
Immunogen This Phc1 antibody was raised against a recombinant mouse Phc1 protein fragment.
Purification Method Protein G
Quantity 10 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13619, 1911
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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