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Invitrogen™ PHD1 Recombinant Rabbit Monoclonal Antibody (3G4)
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Catalog No. PIMA524853
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PIMA524853 100 μL
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Catalog No. PIMA524853 Supplier Invitrogen™ Supplier No. MA524853
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Description

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire. Purity is > 95% by SDS-PAGE.

Prolyl hydroxylase domain proteins HIF PHD1, HIF PHD2 and HIF PHD3 (known as PHD1, PHD2 and PHD3 in rodents, respectively) can hydroxylate HIF-alpha subunits. Hypoxia-inducible factor (HIF) is a transcriptional regulator important in several aspects of oxygen homeostasis. The prolyl hydroxylases catalyze the posttranslational formation of 4-hydroxyproline in HIF-alpha proteins. HIF PHD1, which is widely expressed, with highest levels of expression in testis, functions as a cellular oxygen sensor and is important in cell growth regulation. HIF PHD1 can localize to the nucleus or the cytoplasm and is also detected in hormone responsive tissues, such as normal and cancerous mammary, ovarian and prostate epithelium. HIF PHD1 is encoded by EGLN2, which maps to chromosome 19q13. 3.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PHD1
Applications Immunoprecipitation, Western Blot, Immunocytochemistry, Western Blot
Classification Recombinant Monoclonal
Clone 3G4
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene EGLN2
Gene Accession No. Q6AYU4, Q91YE2, Q96KS0
Gene Alias 0610011A13Rik; C85656; egl nine homolog 2; egl-9 family hypoxia inducible factor 2; egl-9 family hypoxia-inducible factor 2; Egln2; EIT6; EIT-6; Estrogen-induced tag 6; falkor; HIF-1alpha prolyl-4-hydroxylase-1; HIF-P4H 1; Hif-p4h-1; HIFPH1; HIF-PH1; HIF-prolyl hydroxylase 1; HPH-1; HPH-3; Hypoxia-inducible factor prolyl hydroxylase 1; Ier4; immediate early response 4; P4H1; Phd1; PHD-1; Prolyl hydroxylase domain-containing protein 1; SM-20
Gene Symbols EGLN2
Host Species Rabbit
Immunogen Synthetic peptide of human hydroxylase PHD1 (EGLN2) (aa 21-34).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 112398, 112406, 308457
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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