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Invitrogen™ PHEX Polyclonal Antibody
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Catalog No. PIPA5116248
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400 μL
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PIPA5116248 400 μL
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Catalog No. PIPA5116248 Supplier Invitrogen™ Supplier No. PA5116248
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Description

Rabbit Polyclonal Antibody

PHEX Polyclonal Antibody for Western Blot

Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity. Cleaves ASARM peptides between Ser and Glu or Asp residues. Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide. Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides. Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PHEX
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene PHEX
Gene Accession No. P78562
Gene Alias Gy; HPDR; HPDR1; HYP; HYP1; LXHR; metalloendopeptidase homolog PEX; Metalloendopeptidase homolog PEX (Phosphate regulating neutral endopeptidase) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein); PEX; PHEX; phosphate regulating endopeptidase homolog, X-linked; phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets); phosphate regulating neutral endopeptidase; Phosphate regulating neutral endopeptidase on the X chromosome (X-linked hypophosphatemia XLH); phosphate-regulating neutral endopeptidase; Phosphate-regulating neutral endopeptidase PHEX; Vitamin D-resistant hypophosphatemic rickets protein; XLH; X-linked hypophosphatemia protein; X-linked phosphate regulating endopeptidase
Gene Symbols PHEX
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide between 567-595 amino acids from the C-terminal region of human PHEX.
Purification Method Antigen affinity chromatography, Protein A
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5251
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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