Invitrogen™ PHGDH Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA527578

Catalog No. PIPA527578

Description

Recommended positive controls: HeLa, 293T, A431, HeLaS3, mouse brain, SK-N-DZ. Predicted reactivity: Mouse (99%), Rat (97%), Pig (97%), Chimpanzee (100%), Bovine (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

PHGDH gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known.

Specifications

• Antigen: PHGDH
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PHGDH
• Gene Alias: 2-oxoglutarate reductase; 3PGDH; 3-PGDH; 3-phosphoglycerate dehydrogenase; 3-phosphoglycerate dehyrogenase; 4930479N23; A10; D-3-phosphoglycerate dehydrogenase; epididymis secretory protein Li 113; HEL-S-113; Malate dehydrogenase; NLS; NLS1; PDG; PGAD; PGD; PGDH; PGDH3; Phgdh; PHGDHD; phosphoglycerate dehydrogenase; SERA
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 236539, 26227, 58835
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Concentration: 0.87 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: O08651, O43175, Q61753
• Gene Symbols: PHGDH
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 175 of Human PHGDH.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG