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Invitrogen™ PHIP Polyclonal Antibody
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Catalog No. PIPA5110105
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100 μL
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PIPA5110105 100 μL
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Catalog No. PIPA5110105 Supplier Invitrogen™ Supplier No. PA5110105
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KTILENSVKH SKALNTLSSP GQSSFSHGTR NNSAKENMEK EKPVKRKMKS SVLPKASTLS KSSAVIEQGD CKNNALVPGT IQVNGHGGQP SKLVKRGPGR KPKVEVNTNS GEIIHKKRGR KPKKLQYAKP EDLEQNNVHP IRDEVLPSST CNFLSETNNV KEDLLQKKNR GGRKPKRKMK TQKLDADLLV PASVKVLRRS NRKKIDDPID EEEEFEELKG SEPHMRTRNQ GRRTAFYNED DSEEEQRQLL FEDTSLTFGT SSRGRVRKLT EKAKANLIGW.

PHIP (pleckstrin homology domain interacting protein), also known as ndrp or WDR11, is a 1,821 amino acid protein that contains eight N-terminal WD40 repeats and two bromodomains. It is expressed in skeletal muscle (localizing to the cytosol and nucleus) and primary beta cells (localizing to the nucleus) and acts as a transcriptional activator. PHIP is known to interact with various members of the insulin receptor substrate (IRS) family. The IRS family of proteins mediate insulin receptor signaling and play an important role in insulin-producing beta cell proliferation and survival. PHIP specifically associates with the PH domain of IRS-1 and may function to link IRS-1 to insulin receptors, indicating a vital role of PHIP in the regulation of insulin signaling.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PHIP
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene PHIP
Gene Accession No. Q8VDD9, Q8WWQ0
Gene Alias 2810004D21Rik; 4632404O06Rik; BRWD2; DCAF14; DDB1 and CUL4 associated factor 14; DDB1- and CUL4-associated factor 14; FLJ20705; IRS-1 PH domain-binding protein; Ndrp; neuronal differentiation related protein; neuronal differentiation-related protein; PH-interacting protein; PHIP; pleckstrin homology domain interacting protein; WD repeat domain 11; WD repeat-containing protein 11; WDR11
Gene Symbols PHIP
Host Species Rabbit
Immunogen Recombinant Protein (or fragment).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55023, 83946
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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