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Invitrogen™ PHKB Polyclonal Antibody
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Catalog No. PIPA599686
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100 μL
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PIPA599686 100 μL
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Catalog No. PIPA599686 Supplier Invitrogen™ Supplier No. PA599686
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total PHKB.

Phosphorylase kinase is a hexadecameric enzyme that is comprised of four copies of four subunits that are encoded by four separate genes: PHKA, PHKB, PHKG, and PHKD. This serine/threonine specific kinase converts glycogen phosphorylase b to glycogen phosphorylase a, resulting in the release of glucose-1-phophate from glycogen. PHKB (Phosphorylase b kinase regulatory subunit beta) is a 1093 amino acid subunit of phosphorylase kinase that, along with PHKA, has regulatory functions controlled by phosphorylation. Defects in the gene encoding PHKB are the cause of glycogen storage disease type 9B, which is also known as phosphorylase kinase deficiency of liver and muscle. This disease is characterized by a mild phenotype of hepatomegaly with only slightly elevated transaminase and plasma lipids, no clinical muscle involvement, and generally is correlated with a gradual improvement with increasing age. There are four isoforms of PHKB that are produced as a result of alternative splicing events.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PHKB
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene PHKB
Gene Accession No. Q7TSH2, Q93100
Gene Alias AI463271; Phkb; Phosphorylase B; Phosphorylase b kinase regulatory subunit beta; phosphorylase kinase; phosphorylase kinase beta; phosphorylase kinase beta subunit; phosphorylase kinase beta-subunit; phosphorylase kinase regulatory subunit beta; phosphorylase kinase subunit beta; phosphorylase kinase, beta
Gene Symbols PHKB
Host Species Rabbit
Immunogen A synthesized peptide derived from human PHKB(Accession Q93100), corresponding to amino acid residues V206-G256.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 102093, 361377, 5257
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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