Invitrogen™ PHKG2 Polyclonal Antibody

Catalog No.	Quantity
PIPA589590	100 μL

Catalog No. PIPA589590 Supplier Invitrogen™ Supplier No. PA589590

Description

Rabbit Polyclonal Antibody

Immunogen sequence: RQILMLRMIM EGQYQFSSPE WDDRSSTVKD LISRLLQVDP EARLTAEQAL QHPFFERCEG SQPWNLTPRQ RFRVAVWTVL AAGRVALSTH RVRPLTKNAL LRDPYALRSV RHLIDNCAFR LYGHWVKKGE QQNRAALFQH RPPGPFPIMG PEEEGDSAAI TEDEAVLVLG; Positive Samples: MCF-7, 22Rv1, HepG2, Jurkat, 293T, mouse liver, mouse testis, mouse brain, rat liver.

PHKG2 is a testis/liver isoform of the phosphorylase kinase gamma subunit. Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by PHKG2. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in PHKG2 cause glycogen storage disease type 9C, also known as autosomal liver glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in PHKG2.

Specifications

• Antigen: PHKG2
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 1.11 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: PHKG2
• Gene Accession No.: P15735, P31325, Q9DB30
• Gene Alias: 1500017I02Rik; GSD9C; MGC129049 protein; phkg2; PHK-gamma-LT; PHK-gamma-T; Phosphorylase b kinase gamma catalytic chain, liver/testis isoform; phosphorylase b kinase gamma catalytic chain, testis/liver isoform; phosphorylase kinase; phosphorylase kinase catalytic subunit gamma 2; phosphorylase kinase gamma subunit 2; phosphorylase kinase subunit gamma 2; phosphorylase kinase subunit gamma-2; phosphorylase kinase, gamma 2 (testis); Phosphorylase kinase, gamma 2 (testis/liver); PSK-C3; serine/threonine-protein kinase PHKG2; similar to phosphorylase kinase, gamma 2 (testis); zgc:55863; zgc:55863 protein
• Gene Symbols: PHKG2
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 237-406 of human PHKG2 (NP_0002851).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 140671, 5261, 68961
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG