PHLDA1 Monoclonal Antibody (OTI4G2), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA810938

Catalog No. 50-168-3716

Description

Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immunosurveillance against virus-infected or -transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin-based process. Independently, a FAS-based mechanism involves the transducing molecule FAS (APO-1) and its ligand (FAS-L). The human FAS (APO-1) protein is a 48 kDa cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, and is expressed at high levels in T cells subsequent to crosslinking of the T cell receptor (TCR). A previously undescribed protein, TDAG51, restores activation- induced apoptosis in cells that have lost the ability to display Fas in response to activation.

Specifications

• Antigen: PHLDA1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q8WV24
• Gene Symbols: PHLDA1
• Immunogen: Human recombit protein fragment corresponding to amino acids 183-401 of human PHLDA1 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI4G2
• Conjugate: Unconjugated
• Gene: PHLDA1
• Gene Alias: DT1P1B11, PHRIP, TDAG51
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22822
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid