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Invitrogen™ PHLDA1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA5119776
This item is not returnable.
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Description
Positive Control: Mouse brain tissue lysates, human lung carcinoma tissue, human breast tissue, human esophagus tissue, mouse brain tissue. Subcellular Location: Nucleolus. Cytoplasm. Cytoplasmic vesicle.
Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immunosurveillance against virus-infected or -transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin-based process. Independently, a FAS-based mechanism involves the transducing molecule FAS (APO-1) and its ligand (FAS-L). The human FAS (APO-1) protein is a 48 kDa cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, and is expressed at high levels in T cells subsequent to crosslinking of the T cell receptor (TCR). A previously undescribed protein, TDAG51, restores activation- induced apoptosis in cells that have lost the ability to display Fas in response to activation.
Specifications
PHLDA1 | |
Polyclonal | |
Unconjugated | |
PHLDA1 | |
apoptosis-associated nuclear protein; DT1P1B11; PHLDA1; PHRIP; pleckstrin homology like domain family A member 1; pleckstrin homology-like domain family A member 1; pleckstrin homology-like domain, family A, member 1; PQR protein; PQ-rich protein; proline- and glutamine-rich protein; Proline- and histidine-rich protein; proline-histidine rich protein; T-cell death associated; T-cell death-associated gene 51 protein; Tdag; TDAG51 | |
Rabbit | |
Affinity Chromatography | |
RUO | |
21664, 22822 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
1 mg/mL | |
TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4 | |
Q62392, Q8WV24 | |
PHLDA1 | |
Synthetic peptide within human TDAG51 aa 20-60. | |
100 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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