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Invitrogen™ PHLDA1 Polyclonal Antibody
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Catalog No. PIPA5119776
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PIPA5119776 100 μL
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Catalog No. PIPA5119776 Supplier Invitrogen™ Supplier No. PA5119776
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Description

Rabbit Polyclonal Antibody

Positive Control: Mouse brain tissue lysates, human lung carcinoma tissue, human breast tissue, human esophagus tissue, mouse brain tissue. Subcellular Location: Nucleolus. Cytoplasm. Cytoplasmic vesicle.

Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immunosurveillance against virus-infected or -transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin-based process. Independently, a FAS-based mechanism involves the transducing molecule FAS (APO-1) and its ligand (FAS-L). The human FAS (APO-1) protein is a 48 kDa cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, and is expressed at high levels in T cells subsequent to crosslinking of the T cell receptor (TCR). A previously undescribed protein, TDAG51, restores activation- induced apoptosis in cells that have lost the ability to display Fas in response to activation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PHLDA1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Gene PHLDA1
Gene Accession No. Q62392, Q8WV24
Gene Alias apoptosis-associated nuclear protein; DT1P1B11; PHLDA1; PHRIP; pleckstrin homology like domain family A member 1; pleckstrin homology-like domain family A member 1; pleckstrin homology-like domain, family A, member 1; PQR protein; PQ-rich protein; proline- and glutamine-rich protein; Proline- and histidine-rich protein; proline-histidine rich protein; T-cell death associated; T-cell death-associated gene 51 protein; Tdag; TDAG51
Gene Symbols PHLDA1
Host Species Rabbit
Immunogen Synthetic peptide within human TDAG51 aa 20-60.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21664, 22822
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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