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Invitrogen™ PHLPP1 Polyclonal Antibody
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Catalog No. PIPA5103165
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PIPA5103165 100 μL
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Catalog No. PIPA5103165 Supplier Invitrogen™ Supplier No. PA5103165
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total SCOP.

PHLPP1 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. Increased expression of PHLPP1 may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PHLPP1
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene PHLPP1
Gene Accession No. O60346, Q8CHE4, Q9WTR8
Gene Alias AI836256; Circadian Oscillatory Protein (SCOP); EC 3.1.3.16; hSCOP; KIAA0606; mKIAA0606; PH domain and leucine rich repeat protein phosphatase 1; PH domain leucine-rich repeat protein phosphatase 1; PH domain leucine-rich repeat-containing protein phosphatase 1; PH domain-containing family E member 1; Phlpp; PHLPP1; pleckstrin homology domain containing, family E (with leucine rich repeats) member 1; pleckstrin homology domain-containing family E member 1; pleckstrin homology domain-containing family E protein 1; Plekhe1; PPM3A; protein phosphatase, Mg2+/Mn2+ dependent 3A; SCN circadian oscillatory protein; SCOP; Suprachiasmatic nucleus circadian oscillatory protein
Gene Symbols PHLPP1
Host Species Rabbit
Immunogen A synthesized peptide derived from human PHLPP1(Accession O60346), corresponding to amino acid residues G1438-S1488.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23239, 59265, 98432
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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