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Invitrogen™ PHLPP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA534434

Catalog No. PIPA534434


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Description

Description

A suggested positive control is SW480 cell lysate. PA5-34434 can be used with blocking peptide PEP-1476.

PHLPP1 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. Increased expression of PHLPP1 may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

PHLPP1
Polyclonal
Unconjugated
PHLPP1
AI836256; Circadian Oscillatory Protein (SCOP); EC 3.1.3.16; hSCOP; KIAA0606; mKIAA0606; PH domain and leucine rich repeat protein phosphatase 1; PH domain leucine-rich repeat protein phosphatase 1; PH domain leucine-rich repeat-containing protein phosphatase 1; PH domain-containing family E member 1; Phlpp; PHLPP1; pleckstrin homology domain containing, family E (with leucine rich repeats) member 1; pleckstrin homology domain-containing family E member 1; pleckstrin homology domain-containing family E protein 1; Plekhe1; PPM3A; protein phosphatase, Mg2+/Mn2+ dependent 3A; SCN circadian oscillatory protein; SCOP; Suprachiasmatic nucleus circadian oscillatory protein
Rabbit
Antigen affinity chromatography
RUO
23239
Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Liquid
Western Blot, Immunocytochemistry
1 mg/mL
PBS with 0.02% sodium azide
O60346
PHLPP1
An 18 amino acid synthetic peptide near the amino terminus of human PHLPP1.
100 μg
Primary
Human
Antibody
IgG
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