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Invitrogen™ PHLPP1 Polyclonal Antibody
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Catalog No. PIPA534434
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100 μg
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Catalog No. Quantity
PIPA534434 100 μg
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Catalog No. PIPA534434 Supplier Invitrogen™ Supplier No. PA534434
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Description

Rabbit Polyclonal Antibody

A suggested positive control is SW480 cell lysate. PA5-34434 can be used with blocking peptide PEP-1476.

PHLPP1 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. Increased expression of PHLPP1 may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PHLPP1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene PHLPP1
Gene Accession No. O60346
Gene Alias AI836256; Circadian Oscillatory Protein (SCOP); EC 3.1.3.16; hSCOP; KIAA0606; mKIAA0606; PH domain and leucine rich repeat protein phosphatase 1; PH domain leucine-rich repeat protein phosphatase 1; PH domain leucine-rich repeat-containing protein phosphatase 1; PH domain-containing family E member 1; Phlpp; PHLPP1; pleckstrin homology domain containing, family E (with leucine rich repeats) member 1; pleckstrin homology domain-containing family E member 1; pleckstrin homology domain-containing family E protein 1; Plekhe1; PPM3A; protein phosphatase, Mg2+/Mn2+ dependent 3A; SCN circadian oscillatory protein; SCOP; Suprachiasmatic nucleus circadian oscillatory protein
Gene Symbols PHLPP1
Host Species Rabbit
Immunogen An 18 amino acid synthetic peptide near the amino terminus of human PHLPP1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23239
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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