Invitrogen™ PHLPP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110106

Catalog No. PIPA5110106

Description

Immunogen sequence: DSLNLIEVAT EVPKRKTGYF AAPTQMEPED QFVVPHDLEE EVKEQMKQHQ DSRLEPEPHE EDRTEPPEEF DTAL.

Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606). [UniProt].

Specifications

• Antigen: PHLPP2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Phlpp2
• Gene Alias: AI481772; C130044A18Rik; GTPase activating protein and VPS9 domains 1; KIAA0931; PH domain and leucine rich repeat protein phosphatase 2; PH domain leucine-rich repeat-containing protein phosphatase 2; PH domain leucine-rich repeat-containing protein phosphatase-like; PHLPP2; Phlppl; PHLPP-like; PPM3B; protein phosphatase, Mg2+/Mn2+ dependent 3B; RGD1562857
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23035, 244650, 498949
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 0.68 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q6ZVD8, Q8BXA7
• Gene Symbols: Phlpp2
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1250-1323 of human PHLPP2 (NP_0558352).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov