Phorbol 12-myristate 13-acetate, 95%

Description

Activates protein kinase C and promotes skin tumors in mice | CAS: 16561-29-8 | C36H56O8 | 616.84 g/mol

PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.

Solubility
Very soluble in methanol, soluble in DMSO, chloroform, ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble in water.

Notes
Light Sensitive. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Specifications

Chemical Identifiers

• CAS: 16561-29-8
• Molecular Formula: C36H56O8
• Molecular Weight (g/mol): 616.84
• MDL Number: MFCD00036736
• InChI Key: PHEDXBVPIONUQT-RGYGYFBISA-N
• Synonym: phorbol 12-myristate 13-acetate, phorbol ester, 12-o-tetradecanoylphorbol-13-acetate, 12-o-tetradecanoylphorbol 13-acetate, factor a1, tetradecanoylphorbol acetate, 12-tetradecanoylphorbol 13-acetate, factor a1 croton oil, phorbol 13-acetate 12-myristate, phorbol-12-myristate-13-acetate
• PubChem CID: 27924
• ChEBI: CHEBI:37537
• IUPAC Name: (1S,2S,6R,10S,11R,13S,14R,15R)-13-(acetyloxy)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxotetracyclo[8.5.0.0²,⁶.0¹¹,¹³]pentadeca-3,8-dien-14-yl tetradecanoate
• SMILES: CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(C)=O

• Color: White
• Quantity: 1 mg
• Beilstein: 2407201
• Sensitivity: Light sensitive
• Merck Index: 14,7332
• Solubility Information: Very soluble in methanol,soluble in DMSO,chloroform,ethanol or acetone,ether,ethyl acetate,DMF or acetonitrile. Insoluble in water.
• Formula Weight: 616.83
• Percent Purity: >94%
• Physical Form: Film or Powder
• Chemical Name or Material: Phorbol 12-myristate 13-acetate

Safety and Handling

Hazard Category	H315-H319-H335
Hazard Statement	GHS H Statement H315 Causes skin irritation.
Precautionary Statement	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
RTECSNumber	QH4377000
TSCA	No
Recommended Storage	Store at -20°C

SDS

RUO – Research Use Only