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Phorbol 12-myristate 13-acetate, 95%
Description
PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.
Solubility
Very soluble in methanol, soluble in DMSO, chloroform, ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble in water.
Notes
Light Sensitive. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Specifications
Specifications
Color | White |
Quantity | 1 mg |
Beilstein | 2407201 |
Sensitivity | Light sensitive |
Merck Index | 14,7332 |
Solubility Information | Very soluble in methanol,soluble in DMSO,chloroform,ethanol or acetone,ether,ethyl acetate,DMF or acetonitrile. Insoluble in water. |
Formula Weight | 616.83 |
Percent Purity | >94% |
Physical Form | Film or Powder |
Chemical Name or Material | Phorbol 12-myristate 13-acetate |
Safety and Handling
Hazard Category | H315-H319-H335 |
Hazard Statement | GHS H Statement H315 Causes skin irritation. |
Precautionary Statement | P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c |
RTECSNumber | QH4377000 |
TSCA | No |
Recommended Storage | Store at -20°C |
RUO – Research Use Only
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