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  5. Tocris Bioscience™ Phorbol 12-myristate 13-acetate

Tocris Bioscience™ Phorbol 12-myristate 13-acetate
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Catalog No. 12015
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5 mg
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12-015 5 mg
12-011 1 mg
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Catalog No. 12-015 Supplier Tocris Bioscience™ Supplier No. 1201/5
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Description

Protein kinase C activator

Phorbol 12-myristate 13-acetate is an extensively used phorbol ester high affinity activator of protein kinase C (Ki = 2.6 nM as measured by displacement of [3H]phorbol 12,13-dibutyrate binding in rat cortex synaptosomal membranes). It binds to the C1a and C1b domains of PKC inducing membrane translocation of PKC. Phorbol 12-myristate 13-acetate activates the PKC isoforms PKCα, -β, -γ, -δ, -ε, -η, and -θ but not PKCζ or -ι/λ. Phorbol 12-myristate 13-acetate is a tumor promoter. Phorbol 12-myristate 13-acetate can also induce differentiation of THP-1 monocytes to a macrophage phenotype in vitro.

Chemical Identifiers

CAS 16561-29-8
Molecular Formula C36H56O8

Specifications

Quantity 5 mg
Formula Weight 616.83
Purity >99%
Molecular Weight (g/mol) 616.84
Chemical Name or Material Phorbol 12-myristate 13-acetate

Safety and Handling

Recommended Storage Store at -20°C
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