Invitrogen™ Phosphatidylinositol 3,4,5-trisphosphate Monoclonal Antibody (RC6F8)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ A21328

Catalog No. A21328

Description

Phosphatidylinositol 3,4,5-trisphosphate Monoclonal Antibody for ICC/IF

Phosphatidylinositol (3, 4, 5)-trisphosphate (PtdIns(3, 4, 5)P3) commonly abbreviated to PIP3 is the product of the class I phosphoinositide 3-kinases (PI 3-kinases) activity on phosphatidylinositol (4, 5)-bisphosphate. PtdIns (3, 4, 5) P3 is dephophosphorylated by the phosphatase, PTEN on the 3 position and by SHIPs (SH2-containing inositol phosphatase) on the 5' position of the inositol ring. The PH domain in a number of proteins binds to PtdIns (3, 4, 5) P3. Such proteins include Akt/PKB, PDK1, Btk1 and ARNO. The generation of PtdIns (3, 4, 5) P3 at the plasma membrane upon the activation of class I PI 3-kinases causes these proteins to translocate to the plasma membrane and accordingly affects their activity. The PH domain allows binding between PtdIns (3, 4, 5) P3 and G-protein coupled receptor kinases (GRKs). This enhances the binding of the GRK to the plasma membrane. [National Center for Biotechnology Information. PubChem Compound Database; CID=53477782].

Specifications

• Antigen: Phosphatidylinositol 3,4,5-trisphosphate
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% BSA and 5mM sodium azide; pH 7.2
• Host Species: Mouse
• Purification Method: Purified
• Regulatory Status: RUO
• Target Species: Chemical
• Product Type: Antibody
• Isotype: IgM

• Applications: Immunocytochemistry
• Clone: RC6F8
• Conjugate: Unconjugated
• Gene Alias: C12H24O22P4; phosphatidylinositol 3; phosphatidylinositol-3; PIP3
• Immunogen: phosphatidylinositol 3,4,5-diphosphate.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Content And Storage: 4°C
• Form: Liquid
• Target Molecule: Chemical

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov