Invitrogen™ Phospho-Aconitase 1 (Ser711) Polyclonal Antibody

Catalog No.	Quantity
PIPA5114590	100 μL

Catalog No. PIPA5114590 Supplier Invitrogen™ Supplier No. PA5114590

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of IREB1 only when phosphorylated at Ser711.

Aconitase 1 (ACO1) also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). It plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.

Specifications

• Antigen: Phospho-Aconitase 1 (Ser711)
• Applications: Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene: ACO1
• Gene Accession No.: P21399, P28271, Q63270
• Gene Alias: ACO1; Aco-1; Acon1; Aconitase; aconitase 1; aconitase 1, soluble; aconitate hydratase, cytoplasmic; ACONS; AH; Citrate hydro-lyase; cytoplasmic aconitase; cytoplasmic aconitate hydratase; cytosplasmic aconitase; epididymis luminal protein 60; ferritin repressor protein; FRP; HEL60; Ireb1; Irebp; IRE-BP 1; IREBP1; iron regulatory protein 1; iron-responsive element binding protein 1; iron-responsive element-binding protein 1; IRP1; OTTHUMP00000021176; OTTHUMP00000021177; OTTHUMP00000045233; soluble aconitase
• Gene Symbols: ACO1
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human IREB1 around the phosphorylation site of Ser711.
• Purification Method: Sequential Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 11428, 48, 50655
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG