Phospho-Aconitase 1 (Ser711) Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-2504	100 μL

Catalog No. 50-198-2504 Supplier Bioss Supplier No. BS12958R

Description

Rabbit Polyclonal Antibody

Aconitase 1 (ACO1) also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). It plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5′ UTR of ferritin mRNA, and in the 3′ UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.

Specifications

• Antigen: Phospho-Aconitase 1 (Ser711)
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: ACO1
• Gene Accession No.: P21399
• Gene Alias: ACO1; Aco-1; Acon1; Aconitase; aconitase 1; aconitase 1, soluble; aconitate hydratase, cytoplasmic; ACONS; AH; BOS_8623; Citrate hydro-lyase; cytoplasmic aconitase; Cytoplasmic aconitate hydratase; cytosplasmic aconitase; epididymis luminal protein 60; Ferritin repressor protein; FRP; HEL60; IREB1; IREBP; IRE-BP 1; IREBP1; Iron regulatory protein 1; iron-responsive element binding protein 1; Iron-responsive element-binding protein 1; IRP1; OTTHUMP00000021176; OTTHUMP00000021177; OTTHUMP00000045233; soluble aconitase
• Gene Symbols: ACO1
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic phosphopeptide derived from human Aconitase 1 around the phosphorylation site of Ser711 [YG (p-S)RR].
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 48
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG