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Invitrogen™ Phospho-AHNAK (Ser5784) Polyclonal Antibody
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Catalog No. PIPA5105822
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100 μL
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PIPA5105822 100 μL
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Catalog No. PIPA5105822 Supplier Invitrogen™ Supplier No. PA5105822
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of Desmoyokin only when phosphorylated at Ser5784.

AHNAK1 (Desmoyokin) is a large (700 kDa) scaffold protein that translocates to the plasma membrane after an increas of extracellular calcium level or upon proteinkinase C activation and regulates extracellular calcium influx mediated by L-type Ca2+ channels. AHNAK1 has been implicated in diverse signal transduction proceses affecting cell differentiation and proliferation. In response to calcium-dependent intercellular contacts AHNAK1 forms multimeric complexes in the plasma membrane, connected with actin and annexin 2/S100A10 assemblies and is thus involved in organization of the plasma membrane architecture. In epithelial cells, AHNAK1 is localized in cytoplasm or is membrane-associated, but in cells of nonepithelial origin AHNAK1 is predominantly nuclear; it has a weak DNA-binding activity and associates with the DNA-ligase IV-XRCC4 complex.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-AHNAK (Ser5784)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene AHNAK
Gene Accession No. Q09666
Gene Alias AHNAK; AHNAK 1; AHNAK nucleoprotein; AHNAK nucleoprotein (desmoyokin); AHNAK-related; AHNAKRS; Desmoyokin; DY6; MGC5395; Neuroblast differentiation-associated protein AHNAK; PM227; RGD1308572; UV118
Gene Symbols AHNAK
Host Species Rabbit
Immunogen A synthesized peptide derived from human AHNAK(Accession Q09666), corresponding to amino acid residues around phosphorylated Ser5784.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 191572, 66395, 79026
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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