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Invitrogen™ Phospho-AKT1/AKT3 (Tyr437, Tyr434) Polyclonal Antibody
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Catalog No. PA540162
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PA540162 100 μL
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Catalog No. PA540162 Supplier Invitrogen™ Supplier No. PA540162
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Description

Rabbit Polyclonal Antibody

This antibody is predicted to react with mouse and rat based on sequence homology.

AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-AKT1/AKT3 (Tyr437, Tyr434)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene AKT1
Gene Accession No. P31749, P31750, P47196, Q63484, Q9WUA6, Q9Y243
Gene Alias AI851531; Akt; AKT serine/threonine kinase 1; AKT serine/threonine kinase 3; AKT1; AKT1 kinase; AKT1m; Akt1m protein; AKT3; AKT3 kinase; C-AKT; CWS6; D930002M15Rik; EC 2.7.11.1; MPPH; MPPH2; murine thymoma viral (v-akt) oncogene homolog 1; Nmf350; PKB; PKB alpha; PKB gamma; PKB/Akt; PKBalpha; PKB-ALPHA; PKBG; PKB-GAMMA; PRKBA; PRKBG; Protein kinase Akt-3; Protein kinase B; Protein kinase B alpha; protein kinase B gamma; protein kinase B, gamma; protein kinase B-alpha; proto-oncogene c-AKT; RAC; rac protein kinase alpha; RAC protein kinase alpha RAC-PK alpha; RAC-ALPHA; RAC-alpha serine/threonine-protein kinase; RAC-gamma; RAC-gamma serine/threonine protein kinase; RAC-gamma serine/threonine-protein kinase; RAC-PK-alpha; RAC-PK-gamma; related to A and C kinases; serine-threonine protein kinase; STK-2; Thymoma viral proto-oncogene; thymoma viral proto-oncogene 1; thymoma viral proto-oncogene 3; v-akt murine thymoma viral oncogene 3; v-akt murine thymoma viral oncogene homolog 1; v-akt murine thymoma viral oncogene homolog 3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma); v-akt murine thymoma viral oncogene-like protein 1
Gene Symbols AKT1, AKT3
Host Species Rabbit
Immunogen Peptide sequence around phosphorylation site of tyrosine 437 (T-R-Y(p)-F-D) derived from Human AKT1/3.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10000, 11651, 207, 23797, 24185, 29414
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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