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Invitrogen™ Phospho-alpha Actinin 1/2/3/4 (Ser159) Polyclonal Antibody
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Catalog No. PIPA5114548
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PIPA5114548 100 μL
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Catalog No. PIPA5114548 Supplier Invitrogen™ Supplier No. PA5114548
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of ACTN1/2/3/4 only when phosphorylated at Ser159.

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-alpha Actinin 1/2/3/4 (Ser159)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene ACTN1
Gene Accession No. O43707, O88990, P12814, P35609, P57780, Q08043, Q7TPR4, Q9JI91, Q9QXQ0, Q9Z1P2
Gene Alias 1110008F24Rik; 3110023F10Rik; actinin 1 smooth muscle; actinin alpha 1; actinin alpha 2; actinin alpha 3; actinin alpha 3 (gene/pseudogene); actinin alpha 4; actinin, alpha 1; actinin, alpha 2; actinin, alpha 3; ACTININ-4; ACTN1; Actn1a; ACTN2; Actn3; Actn4; alpha actinin 1a; alpha actinin 4; alpha-actinin cytoskeletal isoform; alpha-actinin skeletal muscle; Alpha-actinin skeletal muscle isoform 2; Alpha-actinin skeletal muscle isoform 3; Alpha-actinin-1; alpha-actinin-2; Alpha-actinin-3; alpha-actinin-4; BDPLT15; C77391; CMD1AA; CMH23; F-actin cross-linking protein; focal segmental glomerulosclerosis 1; FSGS; FSGS1; non-muscle alpha-actinin 1; non-muscle alpha-actinin 4; Non-muscle alpha-actinin-1
Gene Symbols ACTN1, Actn2, Actn3, Actn4
Host Species Rabbit
Immunogen A synthesized peptide derived from human ACTN1/2/3/4 around the phosphorylation site of Ser159.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 109711, 11472, 11474, 171009, 291245, 60595, 63836, 81, 81634, 87, 88, 89
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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