Invitrogen™ Phospho-alpha Actinin 1/2/3/4 (Ser159) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5114548

Catalog No. PIPA5114548

Description

Antibody detects endogenous levels of ACTN1/2/3/4 only when phosphorylated at Ser159.

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: Phospho-alpha Actinin 1/2/3/4 (Ser159)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ACTN1
• Gene Alias: 1110008F24Rik; 3110023F10Rik; actinin 1 smooth muscle; actinin alpha 1; actinin alpha 2; actinin alpha 3; actinin alpha 3 (gene/pseudogene); actinin alpha 4; actinin, alpha 1; actinin, alpha 2; actinin, alpha 3; ACTININ-4; ACTN1; Actn1a; ACTN2; Actn3; Actn4; alpha actinin 1a; alpha actinin 4; alpha-actinin cytoskeletal isoform; alpha-actinin skeletal muscle; Alpha-actinin skeletal muscle isoform 2; Alpha-actinin skeletal muscle isoform 3; Alpha-actinin-1; alpha-actinin-2; Alpha-actinin-3; alpha-actinin-4; BDPLT15; C77391; CMD1AA; CMH23; F-actin cross-linking protein; focal segmental glomerulosclerosis 1; FSGS; FSGS1; non-muscle alpha-actinin 1; non-muscle alpha-actinin 4; Non-muscle alpha-actinin-1
• Host Species: Rabbit
• Purification Method: Sequential chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 109711, 11472, 11474, 171009, 291245, 60595, 63836, 81, 81634, 87, 88, 89
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: O43707, O88990, P12814, P35609, P57780, Q08043, Q7TPR4, Q9JI91, Q9QXQ0, Q9Z1P2
• Gene Symbols: ACTN1, Actn2, Actn3, Actn4
• Immunogen: A synthesized peptide derived from human ACTN1/2/3/4 around the phosphorylation site of Ser159.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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