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Phospho-alpha Actinin 1 (Tyr193) Polyclonal Antibody, Invitrogen™

Catalog No. PIPA5105080
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PIPA5105080 100 μL
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Catalog No. PIPA5105080 Supplier Thermo Scientific Supplier No. PA5105080

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of alpha-Actinin only when phosphorylated at Tyr193.

Alpha Actinin 1 belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-alpha Actinin 1 (Tyr193)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene ACTN1
Gene Accession No. P12814, Q7TPR4, Q9Z1P2
Gene Alias 3110023F10Rik; actinin; actinin 1 smooth muscle; actinin alpha 1; actinin, alpha 1; Actn1; Actn1a; alpha actinin 1a; alpha-actinin; alpha-actinin cytoskeletal isoform; Alpha-actinin-1; BDPLT15; F-actin cross-linking protein; fibroblast alpha actinin; FLJ40884; FLJ54432; hypothetical protein; hypothetical protein LOC524770; I79_004057; non-muscle alpha-actinin 1; non-muscle alpha-actinin-1
Gene Symbols ACTN1
Host Species Rabbit
Immunogen A synthesized peptide derived from human ACTN1(Accession P12814), corresponding to amino acid residues around phosphorylated Tyr193.
Purification Method sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 109711, 81634, 87
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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