Phospho-alpha B Crystallin (Ser45) Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-2510	100 μL

Catalog No. 50-198-2510 Supplier Bioss Supplier No. BS12970R

Description

Rabbit Polyclonal Antibody

Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens. The mammalian lens contains 3 major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest of the crystallins and is composed of 2 primary gene products-alpha-A and alpha-B. There are at least 5 different proteins comprising the beta-crystallins. The gamma-crystallins are monomeric, but there are at least 5 gamma crystallins identified in bovine and rat lens. Alpha-Crystallin comprises 40% of total lens protein composition. In addition to maintaining proper refractive index, it also functions in a chaperone like manner by preventing the formation of aggregates possibly leading to cataract formation. It is believed that the phosphorylated states of the alpha-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintenance. Alpha-B crystallin has been linked to Alexander′s disease where it accumulates in brain cells of those afflicted.

Specifications

• Antigen: Phospho-alpha B Crystallin (Ser45)
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: Cryab
• Gene Accession No.: P02511
• Gene Alias: AACRYA; alpha B-crystallin; Alpha(B)-crystallin; alpha-B-crystallin; Alpha-crystallin B chain; alpha-crystallin B chain-like protein; BOS_14343; CMD1II; CRYA2; Crya-2; Cryab; CryAB antibody; crystallin alpha B; crystallin, alpha 2; crystallin, alpha B; crystallin, alpha polypeptide 2; CTPP2; CTRCT16; epididymis secretory protein Li 101; Heat shock protein beta-5; heat shock protein CryAB; heat shock protein HspB5; heat-shock 20 kD like-protein; HEL-S-101; HSPB5; MFM2; P23; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component
• Gene Symbols: Cryab
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic phosphopeptide derived from human alpha B Crystallin around the phosphorylation site of Ser45.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1410
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG