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Phospho-alpha B Crystallin (Ser59) Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501982508
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50-198-2508 100 μL
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Catalog No. 50-198-2508 Supplier Bioss Supplier No. BS12963R
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Description

Rabbit Polyclonal Antibody

Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens. The mammalian lens contains 3 major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest of the crystallins and is composed of 2 primary gene products-alpha-A and alpha-B. There are at least 5 different proteins comprising the beta-crystallins. The gamma-crystallins are monomeric, but there are at least 5 gamma crystallins identified in bovine and rat lens. Alpha-Crystallin comprises 40% of total lens protein composition. In addition to maintaining proper refractive index, it also functions in a chaperone like manner by preventing the formation of aggregates possibly leading to cataract formation. It is believed that the phosphorylated states of the alpha-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintenance. Alpha-B crystallin has been linked to Alexander′s disease where it accumulates in brain cells of those afflicted.

Specifications

Antigen Phospho-alpha B Crystallin (Ser59)
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Cryab
Gene Accession No. P02511
Gene Alias AACRYA; alpha B-crystallin; Alpha(B)-crystallin; alpha-B-crystallin; Alpha-crystallin B chain; alpha-crystallin B chain-like protein; BOS_14343; CMD1II; CRYA2; Crya-2; Cryab; CryAB antibody; crystallin alpha B; crystallin, alpha 2; crystallin, alpha B; crystallin, alpha polypeptide 2; CTPP2; CTRCT16; epididymis secretory protein Li 101; Heat shock protein beta-5; heat shock protein CryAB; heat shock protein HspB5; heat-shock 20 kD like-protein; HEL-S-101; HSPB5; MFM2; P23; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component
Gene Symbols Cryab
Host Species Rabbit
Immunogen KLH conjugated synthetic phosphopeptide derived from human alpha B Crystallin around the phosphorylation site of Ser59.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1410
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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