Invitrogen™ Phospho-alpha Synuclein (Ser129) Recombinant Rabbit Monoclonal Antibody (J18), FITC

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA545931

Catalog No. PIMA545931

Description

A 1:500 dilution of MA5-45931 was sufficient for detection of Alpha Synuclein pSer129 in 10 μg of Mouse Brain by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody. Binds to phosphorylated serine 129 on alpha synuclein. Does not detect unphosphorylated serine 129 alpha synuclein.

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.

Specifications

• Antigen: Phospho-alpha Synuclein (Ser129)
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS, 9.09mM sodium bicarbonate with 640.91mM DMSO, 136.36mM ethanolamine and no preservative; pH 7.4
• Gene Accession No.: O55042, P37840
• Gene Symbols: SNCA
• Immunogen: Human alpha synuclein AA 124-134: AYEMP-pS-EEGYQ-Cys.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Dot Blot, ELISA, Immunohistochemistry, Western Blot, Immunocytochemistry
• Clone: J18
• Conjugate: FITC
• Gene: SNCA
• Gene Alias: Alpha synuclein; alphaSYN; alpha-synuclein; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; Snca; Syn; synuclein alpha; synuclein alpha-140; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor)
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20617, 6622
• Content And Storage: 4°C, store in dark
• Form: Liquid

Safety and Handling

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