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Phospho-APC1 (Ser688) Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501982273
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50-198-2273 100 μL
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Catalog No. 50-198-2273 Supplier Bioss Supplier No. BS12482R
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Description

Rabbit Polyclonal Antibody

Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC1, also known as mitotic checkpoint regulator (MCPR), is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex.

Specifications

Antigen Phospho-APC1 (Ser688)
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene ANAPC1
Gene Accession No. Q9H1A4
Gene Alias 2610021O03Rik; AI047775; AI853536; Anapc1; anaphase promoting complex subunit 1; anaphase-promoting complex 1 (meiotic checkpoint regulator); Anaphase-promoting complex subunit 1; APC1; AW547281; Cyclosome subunit 1; Mcpr; meiotic check point regulator; Mitotic checkpoint regulator; Testis-specific gene 24 protein; Tsg24
Gene Symbols ANAPC1
Host Species Rabbit
Immunogen KLH conjugated synthetic phosphopeptide derived from human APC1 around the phosphorylation site of Ser688.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 64682
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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