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Phospho-Arhgap22 (Ser397)Rabbit anti-Human, Mouse, Rat, Polyclonal, Rockland™
SDP

Catalog No. 501992207
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50 μg
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50-199-2207 50 μg
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Catalog No. 50-199-2207 Supplier Rockland Immunochemicals Supplier No. 600401J12
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Description

Rabbit Polyclonal Antibody

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Anti-ARHGAP22 pS397 is specific for phosphorylated ARHGAP22 at Serine 397. It also recognizes the S22->A mutation but not the S397->A mutation. A BLAST analysis was used to suggest cross-reactivity with Mouse, Rat and Human based on 100% sequence homology. Cross-reactivity with ARHGAP22 pS397 from other sources has not been determined.

GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in down regulation of their active form. ARHGAP22 (Rho GTPase activating protein 22), also known as RHOGAP2, is a 698 amino acid protein that localizes to the cytoplasm, and contains one Rho-GAP domain and one PH domain. ARHGAP22 functions as a GTPase-activating protein for Rac 1 converting it to an inactive GDP-bound state and, through its interaction with ZNF161 (VEZF1), is thought to be useful in transcription regulation. Multiple isoforms of ARHGAP22 exist due to alternative splicing events.

Specifications

Antigen Phospho-Arhgap22 (Ser397)
Applications ELISA, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1.07 mg/mL
Conjugate Unconjugated
Formulation 0.02M potassium phosphate with 0.15M NaCl, 1mg/mL BSA, 50% glycerol and no preservative; pH 7.2
Gene Arhgap22
Gene Accession No. Q7Z5H3, Q8BL80
Gene Alias Arhgap22; B230341L19Rik; p68RacGAP; RHG22; Rho GTPase activating protein 22; Rho GTPase-activating protein 22; RHOGAP2; RhoGap22; Rho-type GTPase-activating protein 22
Gene Symbols Arhgap22
Host Species Rabbit
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 239027, 306279, 58504
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
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