Phospho-Arhgap22 (Ser397)Rabbit anti-Human, Mouse, Rat, Polyclonal, Rockland™

Rabbit Polyclonal Antibody

Supplier:  Rockland Immunochemicals 600401J12

Catalog No. 50-199-2207

Description

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Anti-ARHGAP22 pS397 is specific for phosphorylated ARHGAP22 at Serine 397. It also recognizes the S22->A mutation but not the S397->A mutation. A BLAST analysis was used to suggest cross-reactivity with Mouse, Rat and Human based on 100% sequence homology. Cross-reactivity with ARHGAP22 pS397 from other sources has not been determined.

GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in down regulation of their active form. ARHGAP22 (Rho GTPase activating protein 22), also known as RHOGAP2, is a 698 amino acid protein that localizes to the cytoplasm, and contains one Rho-GAP domain and one PH domain. ARHGAP22 functions as a GTPase-activating protein for Rac 1 converting it to an inactive GDP-bound state and, through its interaction with ZNF161 (VEZF1), is thought to be useful in transcription regulation. Multiple isoforms of ARHGAP22 exist due to alternative splicing events.

Specifications

• Antigen: Phospho-Arhgap22 (Ser397)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Arhgap22
• Gene Alias: Arhgap22; B230341L19Rik; p68RacGAP; RHG22; Rho GTPase activating protein 22; Rho GTPase-activating protein 22; RHOGAP2; RhoGap22; Rho-type GTPase-activating protein 22
• Host Species: Rabbit
• Regulatory Status: RUO
• Gene ID (Entrez): 239027, 306279, 58504
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
• Concentration: 1.07 mg/mL
• Formulation: 0.02M potassium phosphate with 0.15M NaCl, 1mg/mL BSA, 50% glycerol and no preservative; pH 7.2
• Gene Accession No.: Q7Z5H3, Q8BL80
• Gene Symbols: Arhgap22
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody