Phospho-Artemis (Ser516) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA538260

Catalog No. PIPA538260

Description

Distinct DNA repair pathways minimize the consequences of mutagenic events. Reactive oxygen species (ROS) are highly reactive atoms with an unpaired electron that are conducive to double-strand DNA breaking events. Artemis, named after the Greek goddess for the protection of children, is one of the major proteins contributing to the preservation of double-strand breaks in DNA by cutting away the damaged parts of the DNA, which allows the strands to rejoin. Artemis is a single-strand-specific 5′ to 3′ exonuclease that forms a complex with the 469 kDa DNA-dependent protein kinase (DNA-PKcs). DNA-PKcs phosphorylates Artemis, and Artemis acquires endonucleolytic activity on 5′ and 3′ overhangs and hairpins. These activities are essential for V(D)J recombination and for the 5′ and 3′ overhang processing in nonhomologous DNA end joining.

Specifications

• Antigen: Phospho-Artemis (Ser516)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DCLRE1C
• Gene Alias: Protein artemis, DNA cross-link repair 1C protein, Protein A-SCID, SNM1 homolog C, hSNM1C, SNM1-like protein, DCLRE1C, ARTEMIS, ASCID, SCIDA, SNM1C
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 227525, 64421
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q96SD1, Q8K4J0
• Gene Symbols: DCLRE1C
• Immunogen: A synthetic phosphopeptide derived from human Artemis around the phosphorylation site of Ser516 (G-G-SP-Q-S)
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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