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Invitrogen™ Phospho-ASAP2 (Ser701) Polyclonal Antibody
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Catalog No. PIPA5118737
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PIPA5118737 100 μL
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Catalog No. PIPA5118737 Supplier Invitrogen™ Supplier No. PA5118737
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of ASAP2 only when phosphorylated at Ser701.

ASAP2 is a multidomain protein belonging to the beta family with two ANK repeats, an Arf-GAP domain, a PH domain and a SH3 domain. This protein localizes in the Golgi apparatus and also at the plasma membrane where it colocalizes with protein tyrosine kinase 2-beta (PYK2) and forms a stable complex with PYK2 in vivo. ASAP2 is tyrosine phosphorylated by activated PYK2. It functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. ASAP2 activates the small GTPases ARF1, ARF5 and ARF6 and regulates the formation of post-Golgi vesicles and modulates constitutive secretion. It modulates phagocytosis mediated by Fc gamma receptor and ARF6. Usually detected in heart, brain, placenta, kidney, monocytes and pancreas, it is up-regulated during monocyte maturation. Multiple transcript variants encoding different isoforms have been found.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-ASAP2 (Ser701)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene ASAP2
Gene Accession No. O43150, Q7SIG6
Gene Alias 6530401G17Rik; AMAP2; Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; ArfGAP with SH3 domain, ankyrin repeat and PH domain 2; Asap2; centaurin, beta 3; CENTB3; DDEF2; development and differentiation enhancing factor 2; development and differentiation-enhancing factor 2; Gm1523; Gm592; KIAA0400; PAG3; PAP; Pap-alpha; PAPbeta; Paxillin-associated protein with ARF GAP activity 3; PYK2 C terminus-associated protein; pyk2 C-terminus-associated protein; SHAG1
Gene Symbols ASAP2
Host Species Rabbit
Immunogen A synthesized peptide derived from human ASAP2(Accession O43150), corresponding to amino acid residues around phosphorylated Ser701.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 211914, 362719, 8853
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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