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Invitrogen™ Phospho-ASK1 (Ser966) Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA5105027
Description
Antibody detects endogenous levels of ASK1 only when phosphorylated at Serine 966.
MAP3K5 (ASK1) is a serine/threonine kinase that is abundantly expressed in human heart and pancreas and are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activates c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death and a catalytically inactive form of ASK1 inhibited TNF-a-induced apoptosis. ASK1 is expressed in variety of human and mouse tissues.
Specifications
Phospho-ASK1 (Ser966) | |
Polyclonal | |
Unconjugated | |
MAP3K5 | |
7420452D20Rik; apoptosis signal regulating kinase 1; apoptosis signal-regulating kinase 1; ASK; ASK 1; ASK1; ASK-1; EC 2.7.11.25; kinase ASK1; M3K5; MAP/ERK kinase kinase 5; Map3k5; MAPK/ERK kinase kinase 5; MAPKKK5; MEK kinase 5; MEKK 5; Mekk5; mitogen activated protein kinase kinase kinase 5; mitogen-activated protein kinase kinase kinase 5; RGD1306565; RP3-325F22.4 | |
Rabbit | |
Sequential Chromatography | |
RUO | |
26408, 365057, 4217 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
1 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
O35099, Q99683 | |
MAP3K5 | |
A synthesized peptide derived from human MAP3K5(Accession Q99683), corresponding to amino acid residues around phosphorylated Ser966. | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
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