Invitrogen™ Phospho-ASK1 (Ser966) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5105027

Catalog No. PIPA5105027

Description

Antibody detects endogenous levels of ASK1 only when phosphorylated at Serine 966.

MAP3K5 (ASK1) is a serine/threonine kinase that is abundantly expressed in human heart and pancreas and are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activates c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death and a catalytically inactive form of ASK1 inhibited TNF-a-induced apoptosis. ASK1 is expressed in variety of human and mouse tissues.

Specifications

• Antigen: Phospho-ASK1 (Ser966)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MAP3K5
• Gene Alias: 7420452D20Rik; apoptosis signal regulating kinase 1; apoptosis signal-regulating kinase 1; ASK; ASK 1; ASK1; ASK-1; EC 2.7.11.25; kinase ASK1; M3K5; MAP/ERK kinase kinase 5; Map3k5; MAPK/ERK kinase kinase 5; MAPKKK5; MEK kinase 5; MEKK 5; Mekk5; mitogen activated protein kinase kinase kinase 5; mitogen-activated protein kinase kinase kinase 5; RGD1306565; RP3-325F22.4
• Host Species: Rabbit
• Purification Method: Sequential Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26408, 365057, 4217
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O35099, Q99683
• Gene Symbols: MAP3K5
• Immunogen: A synthesized peptide derived from human MAP3K5(Accession Q99683), corresponding to amino acid residues around phosphorylated Ser966.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG