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Invitrogen™ Phospho-ATG13 (Ser355) Polyclonal Antibody
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Catalog No. PIPA572383
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400 μL
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PIPA572383 400 μL
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Catalog No. PIPA572383 Supplier Invitrogen™ Supplier No. PA572383
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Description

Rabbit Polyclonal Antibody

Phospho-ATG13 (Ser355) Polyclonal Antibody for DB

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG13 forms a complex with ULK1 and ULK2, the mammalian homologs of ATG1, and with FIP200. This complex is a target of TOR phosphorylation under normal conditions; inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1 and ULK2, which then leads to autophagy. Knockdown of ATG13 inhibits autophagosome formation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-ATG13 (Ser355)
Applications Dot Blot
Classification Polyclonal
Concentration 0.27 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene ATG13
Gene Accession No. O75143
Gene Alias 1110053A20Rik; Atg13; ATG13 autophagy related 13 homolog; autophagy related 13; autophagy-related protein 13; D2Ertd391e; FLJ20698; Harbi1; Harbi1l; harbinger transposase derived 1; KIAA0652; OTTHUMP00000233321; OTTHUMP00000233322; OTTHUMP00000233323; OTTHUMP00000233324; OTTHUMP00000233325; OTTHUMP00000233326; PARATARG8; RGD1310685
Gene Symbols ATG13
Host Species Rabbit
Immunogen KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S355 of human ATG13.
Purification Method Antigen affinity chromatography, Protein A
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9776
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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