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Phospho-ATM (Ser1981) Polyclonal Antibody, Rockland™
SDP

Sheep Polyclonal Antibody

$174.73 - $636.24

Specifications

Antigen Phospho-ATM (Ser1981)
Concentration 1 mg/mL
Applications ELISA, Immunoprecipitation, Western Blot
Classification Polyclonal
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-199-2567
SDP
Encompass_Preferred
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Rockland Immunochemicals
600601400
100 μg
Each for $636.24
Only null left
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50-199-2568
SDP
Encompass_Preferred
View Documents
Rockland Immunochemicals
600601400S
25 μL
Each for $174.73
Only null left
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Description

Description

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. This affinity-purified antibody is directed against human ATM and is useful in determining its presence in various assays. This polyclonal anti-ATM antibody recognizes the phosphorylated epitope in native and over-expressed proteins found in various tissues and extracts. Reactivity is observed against human ATM and cross reactivity with ATM from other mammalian sources has not been tested.

Ataxia-telangiectasia Mutated (ATM) is a protein that belongs to the PI3/PI4 kinase family. Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and an increased risk of lymphoid cancer. The ATM gene codes for a protein belonging to the phosphoinositide 3-kinase (PI3K) superfamily. ATM phosphorylates proteins instead of lipid and has many downstream targets that act as cell-cycle regulators including: P53, Mdm2, BRCA1, and SMC1. The ATM protein is responsible for repairing double-stranded DNA breaks that occur because of ionizing radiation and other mutagens. The ATM’s C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Studies have shown that ATM becomes autophosphorylated and upregulated by exposure to ionizing radiation. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction. Further, DNA damage caused by ionizing irradiation activates ATM-kinase, leading to a cascade of kinase reactions that regulate cell cycle, apoptosis, and DNA damage repair. Studies have linked ATM to apoptosis along with Nbs1 and Chk2 in the E2F1 pathway.
Specifications

Specifications

Phospho-ATM (Ser1981)
ELISA, Immunoprecipitation, Western Blot
Unconjugated
Sheep
Human
Q13315
472
Primary
Antibody
1 mg/mL
Polyclonal
Liquid
RUO
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
AI256621; AT mutated; A-T mutated; A-T mutated homolog; AT mutated protein; AT1; ATA; Ataxia t; ataxia telangiectasia gene mutated in human beings; Ataxia telangiectasia mutated; Ataxia telangiectasia mutated homolog; ATC; ATD; ATDC; ATE; ATM; ATM (phospho S1981); ATM (pS1981); ATM (pSer1981); ATM phospho S1981; ATM phospho Ser1981; ATM serine/threonine kinase; C030026E19Rik; DKFZp781A0353; EC 2.7.1.37; MGC74674; phospho ATM; phospho S1981 ATM; Serine-protein kinase ATM; TEL1; TEL1, telomere maintenance 1, homolog; TELO1
ATM
-20°C, Avoid Freeze/Thaw Cycles
ATM
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