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Phospho-ATR (Thr1989) Mouse anti-Human, Clone: GT222, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527731

Catalog No. PIMA527731


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Description

Description

Positive Control: HCT116, HCT116(100 J/m2 UVC and recover for 6hr) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.
Specifications

Specifications

Phospho-ATR (Thr1989)
Monoclonal
1.59 mg/mL
PBS with no preservative
Q13535
ataxia telangiectasia and Rad3 related, SCKL1, MEC1, ATR, SCKL, FRP1, FCTCS
Mouse
IgG2b
100 μl
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
545
Immunoprecipitation, Western Blot
GT222
Unconjugated
ATR
Liquid
ATR
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human ATR (phospho Thr1989). The exact sequence is proprietary.
Protein A
RUO
Antibody
Monoclonal
Human
Documents
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