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Invitrogen™ Phospho-ATR (Thr1989) Recombinant Rabbit Monoclonal Antibody (PS01-18)
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Catalog No. PIMA545973
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100 μL
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PIMA545973 100 μL
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Catalog No. PIMA545973 Supplier Invitrogen™ Supplier No. MA545973
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Description

Rabbit Recombinant Monoclonal Antibody

Predicted band size: 301 kDa Positive Control: HeLa cell lysate, HeLa treated with Hydroxyurea cell lysate, HeLa treated with 4mM Hydroxyurea for 20 hours. Subcellular Location: Chromosome, Nucleus. Sequence Similarities: No Cross with Mouse and Rat. Tissue Specificity: Ubiquitous, with highest expression in testis. Isoform 2 is found in pancreas, placenta and liver but not in heart, testis and ovary.

The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-ATR (Thr1989)
Applications Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone PS01-18
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene ATR
Gene Accession No. Q13535
Gene Alias 2310008J16Rik; 2810405N18Rik; ataxia telangiectasia and Rad3 related; ataxia telangiectasia and Rad3-related protein; ATR; ATR serine/threonine kinase; EC 2.7.11.1; FCTCS; FRAP-related protein 1; FRAP-related protein-1; FRP1; I79_000761; kinase ATR; MEC1; MEC1, mitosis entry checkpoint 1, homolog; protein kinase ATR; SCKL; SCKL1; Serine/threonine-protein kinase ATR; TEM8
Gene Symbols ATR
Host Species Rabbit
Immunogen Synthetic phosphopeptide corresponding to residues surrounding Thr1989 of human ATR.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 545
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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