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Invitrogen™ Phospho-B-Myb (Thr494) Polyclonal Antibody
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Catalog No. PIPA5105773
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PIPA5105773 100 μL
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Catalog No. PIPA5105773 Supplier Invitrogen™ Supplier No. PA5105773
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of B-Myb only when phosphorylated at Thr494.

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-B-Myb (Thr494)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Mybl2
Gene Accession No. P10244, P48972
Gene Alias B Myb; Bmyb; B-Myb; HGNC:7548; MGC15600; MYB proto-oncogene like 2; Mybl2; myb-like protein 2; Myb-related protein B; myeloblastosis oncogene-like 2; v-myb avian myeloblastosis viral oncogene homolog-like 2; v-myb myeloblastosis viral oncogene homolog (avian)-like 2; v-myb myeloblastosis viral oncogene homolog-like 2
Gene Symbols Mybl2
Host Species Rabbit
Immunogen A synthesized peptide derived from human MYBL2(Accession P10244), corresponding to amino acid residues around phosphorylated Thr494.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17865, 296344, 4605
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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