Invitrogen™ Phospho-B-Raf (Thr401) Recombinant Rabbit Monoclonal Antibody (4B9)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA533120

Catalog No. PIMA533120

Description

Phospho-B-Raf (Thr401) Recombinant Monoclonal Antibody for Western Blot, ICC/IF, ELISA

BRAF is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It is activated by somatic point mutation in human cancer, and is thought to play a role in the postsynaptic responses of hippocampal neuron. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in B-Raf have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for B-Raf.

Specifications

• Antigen: Phospho-B-Raf (Thr401)
• Classification: Recombinant Monoclonal
• Concentration: 1.3 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P15056, P28028
• Gene Symbols: BRAF
• Immunogen: A synthesized peptide derived from human Phospho-BRAF (T401).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot, Immunocytochemistry
• Clone: 4B9
• Conjugate: Unconjugated
• Gene: BRAF
• Gene Alias: 94 kDa B-raf protein; 9930012E13Rik; AA120551; AA387315; AA473386; Braf; B-raf; B-raf protein; B-raf protein isoform 1; B-raf protein isoform 2; B-Raf proto-oncogene serine/threonine-protein kinase; B-Raf proto-oncogene serine/threonine-protein kinase (p94); B-Raf proto-oncogene, serine/threonine kinase; Braf transforming gene; BRAF1; B-RAF1; Braf2; Braf-2; C230098H17; C87398; C-RMIL; D6Ertd631e; FLJ95109; MGC126806; murine sarcoma viral (v-raf) oncogene homolog B1; NS7; p94; Proto-oncogene B-Raf; proto-oncogene c-Rmil; RAFB1; RMIL; rmil serine/threonine-protein kinase; serine/threonine kinase; serine/threonine-protein kinase B-raf; Serine/threonine-protein kinase Rmil; v-raf murine sarcoma viral oncogene homolog B; v-raf murine sarcoma viral oncogene homolog B1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography, Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 109880, 114486, 673
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid