Invitrogen™ Phospho-BAG3 (Tyr457) Polyclonal Antibody

Catalog No.	Quantity
PIPA564651	100 μL

Catalog No. PIPA564651 Supplier Invitrogen™ Supplier No. PA564651

Description

Rabbit Polyclonal Antibody

Phospho-BAG3 (Tyr457) Polyclonal Antibody detects endogenous levels of BAG3 only when phosphorylated at Tyr457.

BAG3 are among BAG proteins that compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.

Specifications

• Antigen: Phospho-BAG3 (Tyr457)
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: BAG3
• Gene Accession No.: O95817, Q9JLV1
• Gene Alias: AA407278; BAG family molecular chaperone regulator 3; BAG3; BAG-3; BCL2 associated athanogene 3; Bcl-2-associated athanogene 3; Bcl2-associated athanogene 3; BCL2-binding athanogene 3; bcl-2-binding protein Bis; Bcl-2-interacting death suppressor; BIS; CAIR-1; DKFZp434E0610; docking protein CAIR-1; MFM6; mg638; MGC104307; MNCb-2243
• Gene Symbols: BAG3
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human BAG3 (Phospho-Tyr457).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 293524, 29810, 9531
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG