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Invitrogen™ Phospho-BAG3 (Tyr457) Polyclonal Antibody
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Catalog No. PIPA5105968
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PIPA5105968 100 μL
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Catalog No. PIPA5105968 Supplier Invitrogen™ Supplier No. PA5105968
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of BAG3 only when phosphorylated at Tyr457.

BAG3 are among BAG proteins that compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-BAG3 (Tyr457)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene BAG3
Gene Accession No. O95817, Q9JLV1
Gene Alias AA407278; BAG family molecular chaperone regulator 3; BAG3; BAG-3; BCL2 associated athanogene 3; Bcl-2-associated athanogene 3; Bcl2-associated athanogene 3; BCL2-binding athanogene 3; bcl-2-binding protein Bis; Bcl-2-interacting death suppressor; BIS; CAIR-1; DKFZp434E0610; docking protein CAIR-1; MFM6; mg638; MGC104307; MNCb-2243
Gene Symbols BAG3
Host Species Rabbit
Immunogen A synthesized peptide derived from human BAG3(Accession O95817), corresponding to amino acid residues around phosphorylated Tyr457.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 293524, 29810, 9531
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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