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Invitrogen™ Phospho-BCR (Tyr177) Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA517708
Description
It is not recommended to aliquot this antibody.
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
Specifications
Phospho-BCR (Tyr177) | |
Polyclonal | |
Unconjugated | |
Bcr | |
5133400C09Rik; ABL; AI561783; AI853148; ALL; BCR; BCR activator of RhoGEF and GTPase; BCR protein; BCR, RhoGEF and GTPase activating protein; bcr/abl; BCR/FGFR1 chimera protein; BCR1; breakpoint cluster region; breakpoint cluster region homolog; breakpoint cluster region protein; c-ABL; c-abl oncogene 1; CML; D22S11; D22S662; EC 2.7.11.1; FGFR1/BCR chimera protein; JTK7; Kiaa3017; mKIAA3017; p150; PHL; renal carcinoma antigen NY-REN-26; RP11-83J21.1; v-abl | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
110279, 613 | |
-20°C | |
Liquid |
Flow Cytometry, Western Blot | |
229 μg/mL | |
0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5 | |
P11274, Q6PAJ1 | |
Bcr | |
Synthetic phosphopeptide corresponding to residues surrounding pTyr177 of human Bcr. | |
100 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
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