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Invitrogen™ Phospho-beta Arrestin 1 (Ser412) Monoclonal Antibody (H.992.9)
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Catalog No. PIMA515217
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100 μL
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PIMA515217 100 μL
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Catalog No. PIMA515217 Supplier Invitrogen™ Supplier No. MA515217
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Description

Mouse Monoclonal Antibody

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with beta-arrestin 2.

Beta Arrestin 1 is a member of a family of proteins widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling and mediates agonist-dependent desensitization and internalization of Gprotein-coupled receptors (GPCRs, e.g., beta 2-adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G-protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-beta Arrestin 1 (Ser412)
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Clone H.992.9
Conjugate Unconjugated
Formulation 0.01M HEPES with 100 μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5
Gene ARRB1
Gene Accession No. P29066, P49407, Q8BWG8
Gene Alias 1200006I17Rik; ARB1; ARR1; ARRB1; ARRB1 protein; arrdc1; arrestin; arrestin 2; arrestin beta 1; arrestin beta-1; arrestin, beta 1; arrestin-2; AW208571; BARRES; beta-arrestin; beta-arrestin1; beta-arrestin-1; G430100A01Rik; Non-visual arrestin-2
Gene Symbols ARRB1
Host Species Mouse
Immunogen Synthetic peptide corresponding to residues surrounding Ser412 of human β-arrestin 1.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 109689, 25387, 408
Target Species Human, Mouse, Rat, Monkey
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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