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Invitrogen™ Phospho-BLNK (Tyr84) Polyclonal Antibody
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Catalog No. PA126639
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50 μL
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PA126639 50 μL
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Catalog No. PA126639 Supplier Invitrogen™ Supplier No. PA126639
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: EBI cells +/- H2O2 treatment. PA1-26639 is expected to cross react with chicken (83% conserved), mouse (100% conserved) due to sequence homology. The PA1-26639 immunogen is a synthetic phosphopeptide corresponding to a portion of human BLNK containing tyrosine 84. The sequence is conserved in mouse. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

B cell linker protein (Blnk) is a protein encoded by the Blnk gene located on chromosome 10 in humans. It is also known as SLP 65 (Src homology 2 domain-containing leukocyte protein of 65 kDa). It derives its name from being an adaptor protein in the B cell receptor signaling cascade with several supporting studies showing improper development of B cells in the absence of Blnk. Blnk undergoes tyrosine phosphorylation by Syk, a B cell receptor activated kinase, which provides a platform for interaction of signaling intermediaries such as the Vav GEF and Grb2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-BLNK (Tyr84)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene BLNK
Gene Accession No. Q8WV28
Gene Alias AGM4; B cell adaptor containing SH2 domain; B cell linker; B cell linker protein; BASH; bca; B-cell activation; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; B-cell linker; B-cell linker protein; Blnk; BLNK-S; Cytoplasmic adapter protein; LY57; Ly-57; lymphocyte antigen 57; Lyw-57; MGC111051; SLP65; Slp-65; Src homology [SH2] domain-containing leukocyte protein of 65 kD; Src homology 2 domain-containing leukocyte protein of 65 kDa
Gene Symbols BLNK
Host Species Rabbit
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human BLNK around the phosphorylation site of tyrosine 84 (E-M-Yp-V-M).
Purification Method Antigen affinity chromatography
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 29760
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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