Phospho-BRK (Tyr447) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA538413

Catalog No. PIPA538413

Description

The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation.

Specifications

• Antigen: Phospho-BRK (Tyr447)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PTK6
• Gene Alias: BRK, breast tumor kinase, protein-tyrosine kinase 6, protein-tyrosine kinase BRK, tyrosine-protein kinase BRK
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20459, 5753
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Western Blot
• Concentration: 1 mg/mL
• Formulation: Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q13882, Q64434
• Gene Symbols: PTK6
• Immunogen: A synthetic phosphopeptide derived from human Breast Tumor Kinase around the phosphorylation site of Tyr447 (T-S-YP-E-N)
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG