Invitrogen™ Phospho-c-Cbl (Tyr774) Recombinant Rabbit Monoclonal Antibody (CblY774-R3B8), Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA537101

Catalog No. PIMA537101

Description

Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.

Specifications

• Antigen: Phospho-c-Cbl (Tyr774)
• Classification: Recombinant Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.10% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P22681, P22682
• Gene Symbols: Cbl
• Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Tyr774 of human phospho c-Cbl.
• Quantity: 200 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG κ

• Applications: Flow Cytometry
• Clone: CblY774-R3B8
• Conjugate: Unconjugated
• Gene: Cbl
• Gene Alias: 4732447J05Rik; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma; casitas B-lineage lymphoma proto-oncogene; CBL; Cbl proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL2; Cbl-2; CBL-3; CBLC; c-Cbl; E3 ubiquitin-protein ligase CBL; FRA11B; fragile site, folic acid type, rare, fra(11)(q23.3); NSLL; oncogene CBL2; proto-oncogene c-Cbl; RGD1561386; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF55; RNF57; signal transduction protein CBL
• Host Species: Rabbit
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 12402, 867
• Content And Storage: -20°C
• Form: Liquid