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  6. Invitrogen™ Phospho-c-Cbl (Tyr774) Recombinant Rabbit Monoclonal Antibody (CblY774-R4C5), Invitrogen™
  7. PIMA537382

Invitrogen™ Phospho-c-Cbl (Tyr774) Recombinant Rabbit Monoclonal Antibody (CblY774-R4C5), Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA537382

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Catalog No. PIMA537382


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Description

Description

Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Phospho-c-Cbl (Tyr774)
Recombinant Monoclonal
0.5 mg/mL
PBS with 0.10% BSA, 50% glycerol and 0.02% sodium azide
P22681, P22682
Cbl
A synthetic phospho-peptide corresponding to residues surrounding Tyr774 of human phospho c-Cbl.
20 μL
Primary
Human, Mouse
Antibody
IgG κ
Flow Cytometry, Western Blot
CblY774-R4C5
Unconjugated
Cbl
4732447J05Rik; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma; casitas B-lineage lymphoma proto-oncogene; CBL; Cbl proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL2; Cbl-2; CBL-3; CBLC; c-Cbl; E3 ubiquitin-protein ligase CBL; FRA11B; fragile site, folic acid type, rare, fra(11)(q23.3); NSLL; oncogene CBL2; proto-oncogene c-Cbl; RGD1561386; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF55; RNF57; signal transduction protein CBL
Rabbit
Protein A/G
RUO
12402, 867
-20°C
Liquid
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