Invitrogen™ Phospho-C/EBP alpha (Thr222, Thr226) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA517650

Catalog No. PIPA517650

Description

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with other phosphorylated C/EBP isoforms.

The C/EBP (CCAAT/enhancer binding protein) family of transcription factors--alpha, beta, delta, and epsilon)--are widely expressed proteins found in a variety of tissues. These domains contain an evolutionarily conserved five-amino acid motif (the regulatory domain motif RDM) that conforms to the consensus sequence (I/V/L) KXEP. One of the major roles of these transcription factors is that of metabolic regulation in liver and fat cells. Studies suggest that these transcription factors act in a cascade aiding in the development of the adipose cell. Three C/EBP beta isoforms (LAP*, LAP, and LIP) arise from different translation initiation and display different function in gene regulation. From a neurological standpoint, C/EBPs have been implicated in the mediation of nerve growth factor, altering synaptic plasticity, and mediation of inflammatory response in AD patients.

Specifications

• Antigen: Phospho-C/EBP alpha (Thr222, Thr226)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CEBPA
• Gene Alias: C EBP; C/EBP; c/EBP alpha; C/EBPa; C/ebpalpha; C/EBP-alpha; CAAT/enhancer-binding protein DNA-binding protein; CAAT/enhancer-binding protein, DNA-binding protein; CBF-A; CCAAT enhancer binding protein alpha; CCAAT/enhancer binding protein (C/EBP), alpha; CCAAT/enhancer binding protein alpha; CCAAT/enhancer binding protein, alpha; CCAAT/enhancer-binding protein alpha; Cebp; Cebpa; DBPCEP; OTTHUMP00000220269
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1050, 12606
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 278 μg/mL
• Formulation: 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
• Gene Accession No.: P49715, P53566
• Gene Symbols: CEBPA
• Immunogen: Synthetic phosphopeptide corresponding to residues surrounding pThr222/226 of mouse C/EBPa.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG