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Invitrogen™ Phospho-c-Mpl (Tyr626) Polyclonal Antibody
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Catalog No. PIPA5105170
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PIPA5105170 100 μL
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Catalog No. PIPA5105170 Supplier Invitrogen™ Supplier No. PA5105170
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of TPOR only when phosphorylated at Tyr626.

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.
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Specifications

Antigen Phospho-c-Mpl (Tyr626)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene MPL
Gene Accession No. P40238, Q08351
Gene Alias CD110; c-mpl; hlb219; MPL; MPL proto-oncogene, thrombopoietin receptor; MPLV; myeloproliferative leukemia protein; myeloproliferative leukemia virus oncogene; proto-oncogene c-Mpl; THCYT2; thrombopoietin receptor; TPOR; TPO-R
Gene Symbols MPL
Host Species Rabbit
Immunogen A synthesized peptide derived from human MPL(Accession P40238), corresponding to amino acid residues around phosphorylated Tyr626.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17480, 366455, 4352
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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