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Invitrogen™ Phospho-c-Raf (Ser43) Recombinant Rabbit Monoclonal Antibody (SD087-05)
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Catalog No. PIMA532394
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100 μL
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PIMA532394 100 μL
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Catalog No. PIMA532394 Supplier Invitrogen™ Supplier No. MA532394
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Description

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Raf-1 (c-Raf) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
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Specifications

Antigen Phospho-c-Raf (Ser43)
Applications Western Blot
Classification Recombinant Monoclonal
Clone SD087-05
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 40% Glycerol, 0.05% BSA and 0.05% sodium azide; pH 7.4
Gene Raf1
Gene Accession No. P04049, P11345, Q99N57
Gene Alias 6430402F14Rik; AA990557; BB129353; CMD1NN; CRAF; C-RAF; C-Raf proto-oncogene, serine/threonine kinase; Craf1; Craf1 transforming; D830050J10Rik; EC 2.7.11.1; kinase Raf1; murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV); murine sarcoma 3611 oncogene 1; NS5; Oncogene RAF1; OTTHUMP00000207813; OTTHUMP00000209389; proto-oncogene c-RAF; RAF; raf proto-oncogene serine/threonine protein kinase; RAF proto-oncogene serine/threonine-protein kinase; RAF1; Raf-1; Raf-1 proto-oncogene, serine/threonine kinase; sarcoma 3611 oncogene; v-Raf; v-raf-1 leukemia viral oncogene 1; vraf1 murine le; v-raf-1 murine leukemia viral oncogene homolog 1; v-raf-1 murine leukemia viral oncogene-like protein 1; v-raf-leukemia viral oncogene 1
Gene Symbols Raf1
Host Species Rabbit
Immunogen Synthetic phospho-peptide corresponding to residues surrounding Ser43 of Human Raf1 aa 20-69.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 110157, 24703, 5894
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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