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Invitrogen™ Phospho-C5AR1 (Ser327) Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA5118773
Description
Antibody detects endogenous levels of C5R1 only when phosphorylated at Ser327.
CD88, also known as C5aR1, is a C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known. C5AR1 has been implicated in asthma, and its expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract. CD88 is the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Functionally, CD88 stimulates chemotaxis, granule enzyme release and superoxide anion production. CD88 is also a component of the classical pathway of the complement cascade; it may be involved with tissue injury associated with ischemia or sepsis and it may be a component of the membrane attack complex. Diseases associated with CD88 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus.
Specifications
Phospho-C5AR1 (Ser327) | |
Polyclonal | |
Unconjugated | |
C5AR1 | |
anaphylatoxin C5a receptor; C5A; C5a anaphylatoxin chemotactic receptor; C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin receptor; C5a ligand; C5a Receptor; C5AR; C5a-R; C5AR1; C5r1; Cd88; CD88 antigen; complement C5a receptor; complement C5a receptor 1; complement component 5 receptor 1; complement component 5, receptor 1; complement component 5a receptor 1; D7Msu1 | |
Rabbit | |
Sequential Chromatography | |
RUO | |
12273, 728 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
1 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
P21730, P30993 | |
C5AR1 | |
A synthesized peptide derived from human C5AR1(Accession P21730), corresponding to amino acid residues around phosphorylated Ser327. | |
100 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
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