Invitrogen™ Phospho-CaV1.2 (Ser1981) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5106078

Catalog No. PIPA5106078

Description

Antibody detects endogenous levels of CACNA1C only when phosphorylated at Ser1981.

CACNA1C encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by CACNA1C binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins.

Specifications

• Antigen: Phospho-CaV1.2 (Ser1981)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CACNA1C
• Gene Alias: brain class C; CACB; CaCB receptor; CACB-receptor; CACH2; CACH2C; CACH3; Cacn2; CACN4; CACNA 1D; Cacna1c; CACNL1A1; CACNL1A2; calcium channel; calcium channel voltage-dependent alpha1c subunit; calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit; calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; calcium channel, voltage-dependent, alpha 1C subunit; calcium channel, voltage-dependent, L type, alpha 1C subunit; calcium voltage-gated channel subunit alpha1 C; cardiac L-type calcium channel; Cav1.2; CCHL1A1; D930026N18Rik; DHP receptor; DHPR, alpha-1 subunit; I79_006562; long-NT; LQT8; LTCC; L-type calcium channel alpha-1 subunit; MBC; MELC-CC; MGC120730; Mouse brain class C; neuronal voltage-gated calcium channel alpha 1C subunit; Rat brain class C; RATIVS302; RBC; skeletal muscle-specific calcium channel; smooth muscle calcium channel blocker; Smooth muscle calcium channel blocker receptor; TS; unnamed protein product; voltage-dependent L-type Ca2+ channel alpha 1 subunit; Voltage-dependent L-type calcium channel subunit alpha-1C; Voltage-gated calcium channel subunit alpha Cav1.2; voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*
• Host Species: Rabbit
• Purification Method: sequential chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12288, 24239, 775
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P22002, Q01815, Q13936
• Gene Symbols: CACNA1C
• Immunogen: A synthesized peptide derived from human CACNA1C(Accession Q13936), corresponding to amino acid residues around phosphorylated Ser1981.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov